Giants vs. 49ers Thursday Night Football live updates: Score, highlights, biggest plays

The San Francisco 49ers are no strangers to success, but the storied franchise has a chance to get off to a better start than it has in recent years.

With a win Thursday night against the New York Giants, the 49ers will have just their second 3-0 opening in 25 years, with the other such start coming in 2019. Stopping the San Francisco could prove to be a tall task for New York, which will be without Saquon Barkley as the running back recovers from an ankle ailment. The Giants, however, rallied from a 21-point deficit last Sunday to defeat the Arizona Cardinals for their first win of the season.

USA TODAY Sports will have a live breakdown of the game, so check back for more information on all the action:

49ers 17, Giants 6: Graham Gano strikes 56-yard field goal

Darren Waller and the Giants offense showed signs of life late in the first half.

NFL STATS CENTRAL: The latest NFL scores, schedules, odds, stats and more.

Waller had two receptions during New York’s eight-play drive to help put the club in field goal range. After the Giants failed to convert a third down, Gano made a long 56-yard field goal to cut the Giants’ deficit 17-6. — Tyler Dragon

49ers 17, Giants 3: Christian McCaffrey extends San Francisco's lead

Even when Brock Purdy is missing throws, the ball still winds up in hands of 49ers receivers.

Purdy missed Deebo Samuel on a slant route and the ball was deflected high in the air. Rookie wide receiver Ronnie Bell maneuvered underneath the ball, however, and made the contested catch for the first down.


Both 49ers backs are off to productive starts. McCaffrey finished off the drive with a rushing touchdown, his 12th straight game with a score, and is up to 61 yards on the ground. He also has three catches for 26 yards. Elijah Mitchell had a catch for nine yards and a rush for 18 on the drive. On third-and-12 from the red zone, it appeared as if tight end George Kittle was stopped short of the first down. But a roughing the passer call on Leonard Williams – he landed with his full body weight on Purdy, in the eyes of referee Shawn Hochuli – extended the drive and allowed the Niners to extend their lead to 14 points ahead of halftime. — Chris Bumbaca

Darren Waller has goose egg thus far

Darren Waller was expected to be heavily featured in the Giants’ gameplan Thursday night, especially due to the Giants being without running back Saquon Barkley (ankle). However, the Giants' tight end has zero catches and no targets late in the second quarter. Daniel Jones has thrown to six different players, none have been Waller.


Waller came into Thursday night with nine catches and 112 yards in two games. — Tyler Dragon
49ers 10, Giants 3: 2022 Mr. Irrelevant to 2023 seventh-round pick scoring strike

The Niners converted three third downs and were rewarded with a touchdown to make it 10-3.

First, head coach Kyle Shanahan called for a wide-receiver screen on third-and-15 to Deebo Samuel that went for 30 yards. Guard Aaron Banks managed to block two Giants defenders on the play, and Samuel used his block to spring him for the big gain.

From there, McCaffrey took over behind the offensive line with rushes for nine and 10 yards. Facing 3rd-and-13, Shanahan dialed up another screen, this time to McCaffrey, who slipped away for 17 yards. From the Giants’ 11-yard line and facing another third down, Purdy lofted a ball in the front corner of the end zone for wideout Ronnie Bell. The rookie seventh-round pickPurdy was the final pick of the 2022 draft – came down with it and caught his first career touchdown (he had his first career catch earlier in the game).

So far, San Francisco has gotten a first down on six of eight third downs. — Chris Bumbaca

Giants, 49ers tied at the end of first quarter

Reigning NFL Defensive Player of the Year Nick Bosa nearly got a safety late in the first quarter. Bosa came off the line of scrimmage unblocked and sacked Giants QB Daniel Jones right near the goal line. The officials gave Jones forward progress and placed the ball inside the one-yard line. The sack put the Giants in second-and-18 as the first quarter expired with a tie score. — Tyler Dragon

49ers 3, Giants 3: New York answers with field goal of its own

The Giants matched San Francisco’s opening drive field goal with one of their own.

Graham Gano, who kicked the game-winner against the Arizona Cardinals four days ago, drilled a 44-yard field goal to tie the proceedings at 3. New York has scored on six straight possessions going back to the start of that contest’s second half.


Quarterback Daniel Jones connected with four different receivers for 38 total passing yards. He also converted a 3rd-and-1 by barely gaining enough yardage on a sneak. — Chris Bumbaca
49ers 3, Giants 0: San Francisco settles for field goal on opening drive

The 49ers opened up the game with possession of the football. Running back Christian McCaffrey produced 29 yards from scrimmage on and wide receiver Jauan Jennings had a 24-yard catch on third down to put the team in field goal possession.

Kicker Jake Moody made a 28-yard field goal to score the first points of the game. — Tyler Dragon
What time is kickoff for Giants vs. 49ers on 'Thursday Night Football'?

The Giants and 49ers will kick off at 8:15 p.m. ET on Sept. 21.
How can I watch Giants vs 49ers on 'Thursday Night Football'?

Giants vs. 49ers will be streaming on Amazon Prime Video and will be broadcast in local markets only. The game is also available to stream for free on Fubo.


Giants, 49ers inactives for Thursday night: Brandon Aiyuk out

The 49ers will be without starting wide receiver Brandon Aiyuk due to a shoulder injury that he suffered Week 2 versus the Los Angeles Rams. The 49ers also announced that QB Brandon Allen, OL Nick Zakelj, RB Tyrion Davis-Price, LB Jalen Graham, DL Kalia Davis and CB Ambry Thomas are inactive versus New York.

As expected, the Giants will be without starting running back Saquon Barkley because of an ankle injury that he sustained during last week’s win over the Arizona Cardinals. Giants CB Cor'Dale Flott, S Gervarrius Owens, OLB Azeez Ojulari, OL Ben Bredeson, T Andrew Thomas and DL Jordon Riley are also inactive Thursday night.
Giants vs. 49ers odds

The 49ers enter Thursday as 10.5-point favorites, according to BetMGM.NFL Week 3 odds: Moneylines, point spreads, over/under

Giants vs. 49ers predictions

All eight of USA TODAY Sports' NFL experts are rolling with the 49ers, with five of them selecting the game as the lock of the week.

Here's more on what they expect:

Lorenzo Reyes: 49ers 27, Giants 13

Short week and a West Coast trip, New York’s offensive line is a mess and the Giants will be without Saquon Barkley. The Niners are explosive pretty much everywhere. Nick Bosa is going to have a field day.

Tyler Dragon: 49ers 28, Giants 10

The 49ers are the best team in the NFL after two weeks. Brock Purdy is managing the game and getting the football to San Francisco’s explosive playmakers. The 49ers’ defense is once again stout with linebacker Fred Warner and defensive end Nick Bosa leading the way. The Giants will be without Saquon Barkley (ankle), which means it’s going to be a long night for New York.


Victoria Hernandez: 49ers 32, Giants 13

The Giants have good momentum after scoring all 31 points in the second half during their come-from-behind win last week but will struggle again without Saquon Barkley. The 49ers are simply the better team all around.

Jordan Mendoza: 49ers 30, Giants 12

The Giants were able to pull off a miraculous comeback in Week 2, but that was against the lowly Arizona Cardinals. Falling behind the 49ers is not something they’ll be able to overcome – especially without Saquon Barkley – as San Francisco cruises to an easy win.
Betting odds: 49ers among best bets for NFL Week 3

Highlighting Thursday Night Football odds, the San Francisco 49ers are among the best bets for NFL Week 3 in their primetime game against the visiting New York Giants. The undefeated 49ers are favored by 10 points, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.


According to the top NFL betting apps, 49ers quarterback Brock Purdy has some of the best NFL MVP betting odds (+2000) in his second professional season. The 49ers also boast some of the best early Super Bowl betting odds (+600).

The Giants, meanwhile, are not among the most popular NFL future bets after starting 0-2 on the heels of making the playoffs last season. Can Daniel Jones and Co. turn things around in 2023?

Not interested in this game? Our guide to the NFL betting odds, picks and spreads has you covered with Sunday Night Football odds, Monday Night Football odds and more.

If you’re new to sports betting, don’t worry. We have tips for beginners on how to place bet online. And USA TODAY readers can claim exclusive promos and bonus codes with the online sportsbooks and sports betting sites. — Richard Morin

Comments